Editorial Commentary: Platelet-Rich Fibrin Matrix — Is This Stuff for Real?!
Authors: Lall AC, Domb BG
Journal: Arthroscopy. 2018 Mar;34(3):842-843.
DOI: 10.1016/j.arthro.2017.10.018 | PMID: 29502702
Background:
PRP and PRF have gained popularity in orthopedic treatment for tendon and joint pathologies, but clinical evidence remains inconsistent.
Key Points:
- Clinical effectiveness of PRF/PRP is variable and may be partly influenced by placebo effect and patient expectations.
- Psychological factors could play a significant role in perceived benefits.
- Costs and evidence limitations warrant cautious use.
Conclusions:
The true clinical benefits of PRF and PRP are still uncertain.
What Does This Mean for Providers?
- Be cautious when recommending PRF/PRP therapies; ensure patients understand the current lack of definitive proof.
- Manage patient expectations carefully to avoid over-reliance on placebo effects.
- Consider cost-effectiveness and evidence strength when integrating biologics into treatment plans.